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While preliminary evidence supports the adjunctive use of microbiota-targeted therapies alongside conventional hormone replacement, challenges such as individualized intervention design, optimization of microbial formulations, and integration of dietary modulation must be addressed

1025 This risk was not limited to congregate settings such as assisted living residences and nursing homes

doi: 10.1172/JCI59526

However, administration of siRNA lpa1 or AM095 (a lpa 1 inhibitor) mitigated MN injury and protected neurons in SOD1 G93A mice, which thus identifies a potential target in the treatment of ALS [172]