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Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5 adenosine monophosphate-activated protein kinase pathway

Dual 2/3-agonists like ATR-127 enhanced glucose uptake in skeletal muscle and brown adipose tissue, reduced hepatic inflammation, and ameliorated steatosis in diet-induced obesity 55

The multi-system interaction framework provides an integrated potential understanding of PEMs complexity, suggesting that future therapeutic strategies may need to simultaneously target energy metabolism, immune regulation, and neuroprotection to effectively help disrupt this pathological cycle

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