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SECOND OPINION SERIES Natural Treatment for OCD Symptoms: Glutamate, NMDAR, Diet and Biochemical Patterns A natural treatment for OCD symptoms should look beyond serotonin alone and ask whether glutamate overload, NMDA receptor overactivity, undermethylation, copper-zinc imbalance, histamine reactivity, oxidative stress, toxic burden, or mitochondrial strain is driving the intrusive thought loop

As a result, various microbiome interventions like probiotics, prebiotics, specific diets, supplements, fecal microbiota transplantation, pharmacological interventions, improved sleep, and moderate exercise training are potential therapeutic strategies that merit further exploration

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As someone who works in elite sport and values evidence over excitement, Im watching this area with interest, but also with caution