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In addition, intra-myocardial fibrosis, a hallmark of AF, was observed to increase in the atria of obese mice, as evidenced by aggravated collagen deposition, upregulated pro-fibrosis signaling (TGF-, -SMA, Smad3, collagen , and collagen ), and downregulated transcription of anti-fibrotic Smad7 (Figures 2KO)

Kim KA, Kim YS, Park SH, Chung WJ, Choi DH, Jang ES, et al

In 2021, the FDA approved semaglutide for chronic weight management in adults with obesity or overweight under the name Wegovy (Novo Nordisk) [29]