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The Primary Allegations Plaintiffs in the GLP-1 MDL allege: Failure to warn consumers and doctors about the risks of gastroparesis and intestinal obstruction Design defects in the medications Inadequate post-market surveillance and reaction to adverse events Negligent marketing practices that downplayed serious side effects These claims are supported by growing adverse event reports and emerging studies linking GLP-1 medications to prolonged and debilitating digestive disorders

For glycemic control, the mean reduction in HbA1c across most T2DM subgroups approaches or reaches the commonly referenced threshold for clinical relevance of 0.5% 47 , and in key target populations (e.g., T2DM with obesity) can reach 0.81.0%, indicating clinically perceptible improvements

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