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RCT conducted in patients with T2D showed that high doses of tirzepatide represent the most efficacious incretin-based anti-diabetes drug in terms of BW reduction 33 , sustaining the development of the SURMOUNT program to explore its efficacy and safety in the management of obesity 9

The recommended dietary allowance for adults is 2.4 micrograms per day according to the NIH Office of Dietary Supplements (updated 2025)