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Glucagon-like peptide 1 (GLP1) is secreted by intestinal L-cells, regulates glucose homeostasis and has inhibitory effect on gastrointestinal motility ( This study aimed to compare jejunal contractile responses to muscarinic receptor stimulation between obese patients with type 2 diabetes (OB+/DM+) and obese patients without diabetes (OB+/DM), and to assess the effects of GLP-1 and GIP on jejunal contraction in relation to jejunal muscle expression of these peptides, their receptors, and DPP-4

We thank Klaus Schughart for providing Tmprss2 / mice and Giusy Carlino for technical support

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These issues can lead to discomfort and strain in the abdominal muscles, which might indirectly cause lower back pain