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Furthermore, several terms upregulated in old indicate active metabolic detoxification processes (for example, alcohol metabolic process and cellular aldehyde metabolic process), as well as oxidative stress defense (for example, glutathione metabolic process) and remodeling of the extracellular matrix (for example, uronic acid metabolic process, extracellular matrix organization and biological adhesion)

The clinical evidence demonstrates that dual agonism can achieve therapeutic outcomes that substantially exceed those of single-pathway approaches, challenging fundamental assumptions about optimal treatment strategies for diabetes and obesity