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In a study we published in Obesity, I talked to 38 patients about de-escalating their therapy because they had reached a normal weight, and all their laboratory results and metabolic profiles were normal

When that balance is restored, visceral fat dependent on constant metabolic pressure cannot survive

However, these effects are often mild, and appear to dissipate over time with continuous use, with patients treated with liraglutide returning to near-baseline gastric emptying by week 8 of therapy

In the early stages of T2DM, insulin demand increases due to peripheral insulin resistance, when the body compensates by stimulating islet cells to release more insulin, thereby maintaining blood glucose stability