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We hypothesize that (i) the slow inhibition observed in the biochemical assay with the recombinant protein with some of the compounds is due to their preferential binding to a slowly populated conformer of the NADP + -TGR(H) complex and (ii) this conformer is already populated in the worm cell interior accounting for the more rapid inhibition of TGR observed in ex vivo worms with the slow inhibitors

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It is also used to help improve skin radiance, reduce dark spots, and minimise pigmentation caused by sun exposure, acne marks, and melasma by reducing oxidative stress and controlling excess melanin production

Any history of tumors or cancer requires serious medical caution