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Murata K, Kaji K, Nishimura N, Enomoto M, Fujimoto Y, Takeda S, et al

In conclusion, the study robustly demonstrated that FOXO4-DRI selectively eliminates senescent Leydig cells, reduces detrimental SASP factor secretion, improves the testicular microenvironment, and ultimately enhances sperm quality and spermatogenesis in aged mice, positioning it as a promising therapeutic candidate for age-related male infertility [2]

Our team draws on authoritative sources, including systematic reviews published in top-tier medical journals, the latest academic and professional books by renowned experts, and official guidelines from authoritative global health organizations

Mice were sacrificed at 6, 12, and 24 h post-injection through anesthesia followed by exsanguination via open heart puncture