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Semaglutide is classified biochemically as a long-acting, lipidated GLP-1 receptor agonist peptide

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0.6% with placebo at 68 weeks Dose escalation schedule / 0.25 mg weekly for 4 weeks, escalating to 2.4 mg over 16 weeks AAP guideline threshold / pharmacotherapy considered at age 12 or older with obesity Growth monitoring / required at every visit for all pediatric patients on GLP-1 therapy Off-label use in under-12 / not recommended by any major guideline body FDA Approval Covers Ages 12 and Up Only Wegovy received expanded approval from the FDA in December 2022 for adolescents aged 12 years and older with a body mass index at or above the 95th percentile for age and sex [1]

doi: 10.1097/MD.0000000000032885 21 JiangJ.-Y.GaoG.-Y.FengJ.-F.MaoQ.ChenL.-G.YangX.-F.et al