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Incubation of NFT with cell or tissue homogenates, microsomal preparations, or isolated mitochondria revealed one-electron reduction of NFT to yield an NFT radical anion ( NFT ) by flavoprotein-reductases such as xanthine oxidase, aldehyde dehydrogenase, thioredoxin reductase, cytochrome b 5 reductase, and cytochrome P450 reductase (CYPOR) (Miller et al

However, if an NRF2 inhibitor existed, administration of such an inhibitors to cancer-bearing patients may not be so advantageous considering the important role of NRF2 in normal cells for stress response and cytoprotection