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Finally, the panel posited that as IL-23 inhibitors may be able to limit establishment of IL-17/IL-22 memory cells responsible for relapses in psoriasis, trials are needed focussing on early stage treatment
However, FOXO4-DRI treatment significantly reduced the expression of these detrimental SASP factors and, critically, restored the proliferation of GC-1 spg cells in the co-culture system, as evidenced by CCK-8 assays and PCNA expression, without inducing apoptosis in the spermatogonia
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