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Growth hormone secretagogues demonstrate a bell-shaped dose-response curve, meaning that beyond a certain threshold, increasing the dose yields no additional benefit and may reduce receptor sensitivity. Smith et al., Peptides Taking too much Ipamorelin can lead to diminished returns , or worse, GH resistance , where your body adapts and no longer responds

Salzmann, G

Circulation 105(3):373379 Aiello LP, Wong J-S (2000) Role of vascular endothelial growth factor in diabetic vascular complications

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