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Dysregulation in HGF/c-MET signaling leading to uncontrolled proliferation, motility, invasiveness, and angiogenesis can play an essential role in the development, progression, and survival of cancer including HNSCC

The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

This medication passes into breast milk