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However, a statistically-significant and dose-related increase in the incidence of pancreatic adenomas was observed in the male rats fed 4 or 8 mg/kg

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Damage to the tubular endothelial cells can increase leukocyte adhesion, platelet aggregation, and vasoconstriction, reduce blood flow to nephrons, and damage the glomerular barrier and the extensive network of peritubular capillaries (88)