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Three decades of valproate: a current model for studying autism spectrum disorder

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showed that brain oxidative stress induced by central or peripheral LPS injection is modulated by AT 1 -R, preventing its development by previous CAND or losartan oral administration ( via i.c.v.) induced oxidative stress, which is prevented by central injection of AT 1 -R blockers or angiotensin-converting enzyme inhibitors ( 1 -R, via phospholipase C 1 ( 1 -R may be involved in neurotoxicity effects of others amphetamines derivatives such as 3,4-methylenedioxymethamphetamine