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demonstrated that amino acids and TCA cycle intermediates were elevated in ovarian cancer tissues ( via enhancing angiogenesis, and decreased cell adherence ( via an anaplerotic reaction of the TCA cycle intermediate -ketoglutarate, which contributes to redox balance and increase NADH production for the proliferation of cancer cells (59, 60)

However, anti-doping regulations evolve, and metabolic modulators are an area of ongoing regulatory attention

These proteins contain structural domains that facilitate communication within the niche by interacting with a diverse array of signaling molecules, including growth factors [such as transforming growth factor beta (TGF-), platelet-derived growth factor (PDGF), and Wnt ligands], cell surface receptors, and cytokines

The heterogeneity of PCOS necessitates individualization of treatment options, and it appears that exercise combined with additional dietary/drug intervention is better for improving insulin sensitivity than either intervention alone [149,150,151]