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Endometriosis is caused by mechanisms including: Chronic inflammation Estrogen dominance or impaired estrogen clearance Immune dysregulation Oxidative stress Gut and microbiome imbalance Nervous system sensitization and pain signaling That means that the most effective supplements for endometriosis tend to fall into a few key categories: Anti-inflammatory supplements for endometriosis: A big trigger of endometriosis is chronic, systemic inflammation, not just inflammation during menstruation