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cAMP activates PKA and Epac-2 signal transduction pathways, PKA and Epac-2 lead to the closure of ATP-sensitive potassium channels, which in turn causes depolarization of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of insulin granules and blood glucose control of T2DM patients

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Wilding JP, Woo V, Rohwedder K, Sugg J, Parikh S

One may argue that our findings are less relevant to TBI in patients because we administered Immunocal orally to mice for 28 days prior to inducing TBI