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10.1016/j.ccell.2014.12.006 Cancer Cell 91 JonesD

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Side Effects: Sedation Parkinsonism symptoms QT prolongation (may be significant if taking with drugs inhibiting CYP3A4/5 or 2D6) Pharmacokinetics: undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 deuterated active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug twice a day dosing effect half life 9.4 hours (Schneider et al, 2021) HT: Resistant Hypertension

Compound Specifications CAS 946870-92-4 MW 9111.6 g/mol Formula C400H625N111O115S9 Purity Testing in progress Documentation & Lab Use Form: Lyophilized research material Documentation: Review the product label, batch records, and applicable laboratory SOPs before accessioning