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Limitations and Considerations BMI cutoff used is in between the typical cutoffs for overweight and obese Limited generalizability given that the majority of patients included were Caucasian, with only 12.5% African American male predominant population studied, with only 27.7% females It remains to be demonstrated if treatment with semaglutide has a cardioprotective and preventative benefit in patients who do not have pre-existing cardiovascular disease PowellWiley TM, Poirier P, Burke LE, et al

This makes disease monitoring more difficult and can lead to delayed recognition of flares

How tirzepatide works Mimics gut hormones Tirzepatide mimics the hormones GLP-1 and GIP

Patients should not discontinue Ozempic without consulting their prescriber, as abrupt cessation may affect glycaemic control