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[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Lobo V., Patil A., Phatak A., Chandra N

They are also critical for managing chronic kidney disease and lowering the risk of heart failure

When to Stop Some situations call for discontinuation, not just an off-cycle: Active or recently diagnosed malignancy New uncontrolled diabetes New thyroid abnormality Persistent side effects that carry across multiple cycles You've reached your goal and don't need maintenance The boring truth is that the last one applies more often than people admit