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Readers seeking the receptor-level rationale behind these findings may consult the companion retatrutide mechanism of action article, while the retatrutide research overview situates the compound within its pharmacological class

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I-cell intracellular calcium levels were increased upon stimulation by different chain-length fatty acids (acetate, butyrate, decanoate, and laurate (each at 1 mM), eicosapentaenoic acid (EPA, 200 microM) and AM1638 (FFAR1 agonist ,10 microM), whereas the FFAR4 agonist (TUG-891, 1 microM) did not increase intracellular calcium levels

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