European Polymer Journal Research by Arn Mignon et al., published in European Polymer Journal
Such impairments closely parallel the mitochondrial respiratory deficits and elevated oxidative markers reported in cortical and limbic regions of depressed individuals, which would impair energy-dependent neuroplastic processes, intracellular signal transduction cascades, and activity-dependent protein synthesis required for synaptic maintenance, dendritic remodelling, and adaptive circuit function [138, 143]
In patients treated with escitalopram for 12 weeks, clinical remission was accompanied by serum reductions in neurotoxic KP metabolites, including 3-HK and QA, and a shift in metabolite ratios favouring a less excitotoxic profile (e.g., reduced QA/3-HK and increased KYNA/QA) [192]
Glycine is an amino acid rather than an enzyme-inhibiting drug, but it may still interact with other medications through pharmacodynamic and physiologic mechanisms