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PE-22-28 Safety Considerations# PE-22-28's safety profile is less burdened by mechanism-specific concerns: TREK-1 channels are expressed throughout the body (brain, heart, vasculature, gastrointestinal tract), so systemic TREK-1 blockade could theoretically affect cardiovascular function, pain sensation, and gastrointestinal motility

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Concept of LoS scoring and on the adaptability of our findings in clinical practice As means to quantifying the suitability of a persons airway for the LoS spray protocol, we exploratorily propose a scoring system that is based on how much of the targeted drug delivery sites (OMC, sinuses) are visible when inspected clinically from outside of the nostril

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