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Anything promoted as an injectable cure for knee problems should be treated with caution.

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True copper allergy typically produces hives, swelling, or systemic symptoms beyond localized skin changes

An advantage of the methods of sterilization provided herein is that, in certain instances, the formulations are subjected to terminal sterilization via autoclaving without any loss of the active agent and/or excipients and/or polymeric components during the sterilization step and are rendered substantially free of microbes and/or pyrogens