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Future investigations should focus on understanding the role of NLRP3 at different phases of APAP-induced liver injury, its activation in various cell types, including hepatocytes and Kupffer cells, and validating its involvement in liver damage in multiple animal models through comparative analyses

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There was a non-significant trend to upregulation of VSIR , encoding inhibitory checkpoint V-domain Ig suppressor of T cell activation (VISTA), in IGF-treated DU145 and 22Rv1 cells and no detectable Vsir in Myc-CaP (Supplementary Figure S4A-B)