In the diabetes TRIUMPH-2 trial, reported side effects included: Diarrhea (around 27 to 34 percent of participants, depending on the dose) Nausea (14 to 28 percent) Constipation (14 to 17 percent) Decreased appetite (6 to 17 percent) Vomiting (6 to 16 percent) In the TRIUMPH-3 trial for adults with severe obesity and heart disease, participants reported: Diarrhea (around 24 to 30 percent of participants, depending on the dose) Nausea (22 percent) Constipation (16 to 18 percent) Decreased appetite (14 to 15 percent) Hyperglycemia, or high blood sugar (3 to 4 percent) The high rates of diarrhea surprised Ali
Healthy older men with normal body weight usually do not experience a significant drop in testosterone levels in their blood, and there is no such thing as male menopause or andropause
These disorders may have normal or accelerated gastric emptying the later of which is seen with dumping syndrome
combined with the impact of gastrointestinal reactions on the absorption and adherence of oral contraceptives, the risk is further amplified, particularly during the initiation or dose-escalation phases of tirzepatide (161, 162, 169)
