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(b) Methodology To Estimate the Cost Performance Category Score We estimated the cost performance category score using a methodology similar to the methodology described in the CY 2025 PFS final rule (89 FR 98531) for the baseline and the proposed policies RIA models with the modifications described later in this section

Nevertheless, as the finalized policies will increase accuracy and transparency of ASP reporting, we anticipate that the finalized policy will likely result in reduced drug spending overall, resulting in decreases in ASP

In the absence of Clic4 or Schnurri-2, TGF-beta signalling is abrogated

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