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It also acts as an excitatory neurotransmitter and plays a significant role in the sleep-wake cycle

According to NICE Technology Appraisal 875, Wegovy should be prescribed within a specialist weight management service, with a maximum treatment duration of 2 years, and continued only if at least 5% weight loss is achieved at 6 months

Lifestyle Foundations: Consistent strength training (essential for preserving muscle mass and bone density in perimenopause), 7-8 hours of quality sleep, protein adequacy, and sustainable stress management practices are established and maintained