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Cerebral Vascular Dysfunction and Cholesterol Homeostasis in the Brain Cerebral vascular dysfunction in the brain Based on previous studies, cerebral infarction and cerebro-atherosclerosis caused by cerebral vascular dysfunction occur in 80% of ischemic strokes and 20% of parenchymal hemorrhagic strokes worldwide (19, 20)

158 Conversely, a clinical trial investigating intravenous or intragastric alcohol administration reported no significant alterations in plasma GLP-1 concentrations in healthy male volunteers

Dysfunction of CI is a defining feature of circadian disruption and diet-induced obesity in adipose tissue, linking clock misalignment to visceral adipocyte hypertrophy, ectopic lipid deposition in liver and impaired glucose tolerance

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