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Life Sci 305:120786
As GPX4 serves as the master regulator of lipid hydroperoxide reduction, its suppression triggers irreversible lipid peroxide accumulation that culminates in ferroptotic cell death ( Complementing this primary mechanism, emerging evidence indicates that SFN modulates iron metabolism through upregulation of ferritin heavy chain (FTH1), potentially altering intracellular iron homeostasis to promote iron-mediated lipid peroxidation via Fenton chemistry ( 4.3 Targeting CSCs through coordinated pathway disruption SFN demonstrates remarkable efficacy against CSCs through its ability to simultaneously disrupt multiple signaling pathways that maintain stemness and self-renewal capacity
Vitamin A and Alzheimer's disease
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