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In-vivo imaging of bloodbrain barrier permeability using positron emission tomography with 2-amino-[3-11C] isobutyric acid

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To study the permeability of nanoparticles in vitro BBB models, which conform to the 3R principles with the minimalization the number of animal experiments, are widely used either in static [34] or in dynamic conditions by employing lab-on-a-chip systems [35]

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