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As a result, the increased secondary BAs can activate TGR5, which increases L-cells and GLP-1 secretion by inhibiting the RhoA/ROCK pathway and inducing YAP activation [157, 203]
Individuals suffering from pre-existing health conditions such as pancreatitis, decreased kidney function, low blood sugar, multiple endocrine neoplasia type 2, gallbladder disease, and diabetic retinopathy should avoid Semaglutide treatment
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