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Consistent with a role of vagal afferents and vagal afferent GLP-1 receptors in the eating-inhibitory effect of peripheral endogenous GLP-1, virus-mediated knockdown of GLP-1R in vagal afferent neurons increased meal size, accelerated gastric emptying, and reduced prandial insulin secretion in rats, while not affecting 24 h food intake or body weight [518]

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The mean duration of type 2 diabetes mellitus was 3.5 years and the mean BMI was 32 kg/m2