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Weight Loss Results: Comparing Clinical Evidence Metformin typically produces modest weight loss of 23 kg over months when used alone, primarily through improved metabolic function rather than appetite suppression

The researchers further compared all-cause mortality, sepsis- and infection-related mortality, and mortality related to major adverse cardiovascular and cerebrovascular events between patients treated with GLP-1 receptor agonists and patients treated with DPP-4 inhibitors

This dual action is why these medications can lead to significant weight loss

rbmojournal.com Weight Loss Benefits of GLP-1 Receptor Agonists: Studies have shown that GLP-1 receptor agonists significantly reduce body weight and fat mass, contributing to improved metabolic profiles in PCOS patients