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GTP cyclohydrolase-1 (GCH1) can catalyse GTP to tetrahydrobiopterin to exert endogenous antioxidant effects and inhibit ferroptosis [79]

Regular follow-up matters Check-ins with a doctor help make sure the dose is still correct, side effects are managed, and health markers like blood pressure and cholesterol are improving

Moreover, properly harnessing the Nrf2/HO-1 axis while managing its potential pro-ferroptotic risks may help maintain redox balance and curb iron overload, thereby offering an additional strategy to alleviate ferroptosis-driven damage in OA (202)

Each blister pack contains 4 tablets (10 mg per tablet)