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Induction of programmed cell death Alcoholic liver disease, decompensated cirrhosis, and pharmacological liver injury all cause sustained hepatocellular and tissue damage, leading to the release of DAMPs such as HMGB1, extracellular histones, and mtDNA

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such adenomyotic lesions can invade posterior uterine and cervical walls, extending into the rectovaginal space and digestive tract to cause mechanical obstruction ( Tubal involvement further contributes to infertility, as endometriotic lesions in the fallopian tube subserosal layer are strongly associated with reproductive impairment

doi: 10.3390/toxins13050294 138 ZhuR.FeussnerK.WuT.YanF.KarlovskyP.ZhengX