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One caveat specific to retatrutide is the observed transient increase in heart rate , which rose early, peaked around week 24, and then declined over the remainder of the phase 2 trial

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The detergent and salt concentrations were lowered by washing with 2 1 ml low-salt buffer (150 mM NaCl, 20 mM TrisHCl 7.5, 5 mM choline chloride, 0.02% DDM, 0,002% CHS)