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It can increase the thermogenesis and utilization of triacylglycerol-derived fatty acids and glucose in brown adipocytes and reduce the lipid content through the central GLP-1R agonists signaling pathway, such as central AMP-activated protein kinase or sirtuin-1 (SIRT1), also known as NAD-dependent deacetylase SIRT1 (3639)

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If a target compound is present above a threshold concentration, the antibody binds to it and triggers a detectable signal

GLP-1RAs, such as liraglutide, have been shown to activate brown adipose tissue (BAT) via CNS pathways, promoting thermogenesis and increasing energy expenditure independently of food intake [238240]