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Although in early studies the ocular effects of DMSO were considered contradictory and there was no systematic examination of DMSO-based formulations in ophthalmic clinical trials, today, growing evidence confirms the feasibility of this compound as a cosolvent in topical medication for the treatment of a wide range of ophthalmological conditions, including superficial keratitis, blepharoconjunctivitis, blepharitis and glaucoma [64,65,66,67]

Lashuel et al., 2013)

This could be daily, weekly, monthly, or at other intervals appropriate for your physiology

On the Arizona Trail, I watched a hiking partner's condition deteriorate over a single hot afternoon because she was drinking plenty of water but not replacing what she was sweating out