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Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data

These data indicate that the disulfide bonds of both E127 ECD CQ211 ECL1 C and Q37 ECD CL379 ECL3 C are formed on the native protein in the absence of the antibody, strengthening the hypothesis that the current structure represents a physiologically relevant inactive conformation of GLP-1R

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For medications like liraglutide, this ensures that the clinical effects, including weight reduction and gastrointestinal side effects, should be essentially identical, says Michael Genovese, MD, chief medical adviser at AscendantNY in New York City