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Measurable changes in body composition typically become noticeable after 8 to 12 weeks of consistent use

Maintenance of both mitochondrial quantity and quality is strictly related to the conservation of an adequate concentration of several proteins, such as PGC-1, TFAM, mitochondrial cristae biogenesis protein optic atrophy 1 (Opa1), Drp1, Mitofusin 1 (Mfn1), Mitofusin 2 (Mfn2), mitochondrial fission protein 1 (FIS1), PINK1, Parkin, VDAC1, Bnip3, and Nix, reunited in the process of proteostasis (Moreira et al., 2017