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A number of positive anti-inflammatory actions of thiamine include activation of Nrf2 and decreased ROS levels, enhanced activity of mitochondrial respiratory chain complexes I-IV, downregulation of endoplasmic reticulum stress, and suppression of gene expression associated with mitophagy, oxidative stress, and proinflammatory cytokines (205)

The above data indicated that dietary carnitine supplementation could increase the in vivo carnitine concentration and reduce the TG content in the liver and muscle

It requires a daily commitment to subcutaneous injections, as oral forms are highly ineffective

doi:10.1016/j.mito.2020.11.010