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Often it appears as: a pigmented patch or nodule with irregular shape with uneven coloration The color may include: brown and black blue, reddish, or whitish tones Over time, the lesion may develop: thickening bumpiness ulceration or bleeding A useful guideline is the ABCDE rule: asymmetry irregular borders multiple colors diameter greater than ~56 mm changes over time Melanoma can appear anywhere on the body
Indeed, during endogenous metabolic reactions, oxygen radicals such as superoxide anion, hydrogen peroxide, hydroxyl radicals, and oxygen peroxides are produced as normal molecular oxygen products in the mitochondria 43
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