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Inhibitors do not convert TGR into an NADPH oxidase Several covalent inhibitors of TGR are electrophilic compounds reacting with the Sec residue at the C-terminus, which induce a transition in the enzyme from an antioxidant to a pro-oxidant with increased NADPH consumption 20,45

In certain scenarios, extended survival might coincide with a decline in the quality of life

Yamazaki N, Shinohara Y, Shima A, Yamanaka Y, Terada H: Isolation and characterization of cDNA and genomic clones encoding human muscle type carnitine palmitoyltransferase I