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Journal of Clinical Medicine, December 2025

Critical Considerations & Current Status Investigational Drug: Cagrilintide is NOT approved for any use

The range of gallbladder complications linked to Ozempic spans from mild to life-threatening: Acute cholecystitis requiring emergency hospitalization and surgical intervention Cholelithiasis (gallstones) causing severe right upper quadrant pain, especially after fatty meals Biliary colic with episodes of intense pain lasting hours Choledocholithiasis where stones migrate to the common bile duct causing obstruction Ascending cholangitis, a life-threatening infection of the bile ducts Pancreatitis secondary to gallstone migration Post-cholecystectomy syndrome with ongoing digestive problems after gallbladder removal Increased surgical risks due to delayed gastric emptying affecting anesthesia safety FDA investigations revealed particularly concerning patterns, with 47% of acute cholecystitis cases developing within 90 days of starting Ozempic, suggesting an immediate and dramatic effect on gallbladder function

This suggests that it is primarily the amount of GLP-1 circulating in the body that determines how much reaches the joint, he says