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Although these classical inhibitors show great potential in preclinical research, their clinical translation still faces substantial obstacles, including poor metabolic stability, suboptimal pharmacokinetics, and the critical fact that no anti-ferroptosis drug has yet entered human trials

What We Do Not Know We lack peer reviewed data defining systemic exposure thresholds, tissue distribution, immunogenicity rates, potential peptide related impurities impact, chronic dosing safety, interaction with existing pathologic angiogenesis (e.g